Реакция #985298

Уравнение реакции

N,O-dimethyl-hydroxylamine HCl

Triethylamine

cyclopropanecarbonyl chloride

→

colorless oil

Выход 61.4%

Cyclopropanecarboxylic acid methoxy-methyl-amide

Выход 61.4%

Растворители

DCM

Условия реакции

Обработка

1. 1
   Температураcooled in ice
2. 2
   Температураwithout cooling
3. 3
   ЭкстракцияExtraction
4. 4
   workup.DISTILLATIONDistillation
5. 5
   Другое75° C./20 mbar

Методика

N,O-dimethyl-hydroxylamine HCl (40 g, 410 mmol) was suspended under nitrogen in DCM (400 mL) and cooled in ice. Triethylamine (63 mL, 451 mmol) was added slowly, then cyclopropanecarbonyl chloride (41 mL, 451 mmol) was added slowly. Stirring without cooling was continued for 1 h. Extraction: 2×DCM, 1×1 N HCl, 1×NaCl. Distillation: 75° C./20 mbar. One obtained 32.5 g (61%) of a colorless oil.

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