Реакция #985261

Уравнение реакции

4-nitrobenzoyl chloride

2-aminothiophenol

→

product

Выход 73.2%

2-(4-Nitrophenyl)benzothiazole

Выход 73.2%

Растворители

benzene

Условия реакции

Обработка

1. 1
   ДругоеThe reaction was quenched with water (20 mL)
2. 2
   ДругоеThe aqueous layer was separated
3. 3
   Экстракцияextracted with ethyl acetate (3×10 ml)
4. 4
   ДругоеThe combined organic layers were dried
5. 5
   Другоеevaporated
6. 6
   ДругоеThe crude product was purified
7. 7
   Другоеwith flush column, (hexane:ethyl acetate=85:15)

Методика

A solution of 4-nitrobenzoyl chloride (1.49 g, 8.0 mmol) in benzene anhydrous, 10 mL) was added dropwise to 2-aminothiophenol (1.0 g, 8.0 mmol in 10 ml of benzene) at room temperature. The reaction mixture was allowed to stir for 16 hr. The reaction was quenched with water (20 mL). The aqueous layer was separated and extracted with ethyl acetate (3×10 ml). The combined organic layers were dried and evaporated. The crude product was purified with flush column, (hexane:ethyl acetate=85:15) to give 1.5 g (73.2%) of product as light yellow solid.

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