Реакция #975502

Уравнение реакции

Methacryloyl chloride

AlCl3

HCl

indane

→

product

Выход 83.3%

2-methyl-3,5,6,7-tetrahydro-s-indacen-1(2H)-one

Выход 83.3%

Растворители

CH2Cl2

Условия реакции

Обработка

1. 1
   workup.STIRRINGwas stirred overnight
2. 2
   ДругоеNext day the mixture obtained
3. 3
   ДругоеThe organic phase was separated
4. 4
   Промывкаwashed with water and 5% NaHCO3
5. 5
   Сушкаdried over MgSO4
6. 6
   ДругоеSolvent was evaporated
7. 7
   workup.DISTILLATIONresidue was distilled in vacuum

Методика

Methacryloyl chloride (50 ml, 0.5 mol) was added to a suspension of 133.5 g (1 mol) AlCl3 in 500 ml CH2Cl2 at −78° C. and stirred for 20 min. Then 59 g (0.5 mol) indane was added at the same temperature. The mixture was allowed to warm to room temperature and then was stirred overnight. Next day the mixture obtained was poured carefully into a mixture of ice (1000 g) and HCl (200 ml). The organic phase was separated, washed with water and 5% NaHCO3, and dried over MgSO4. Solvent was evaporated and residue was distilled in vacuum giving 77.6 g of product (83%), b.p. 118-120° C./0.5 torr.

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