Реакция #9750

Уравнение реакции

water

ethyl[2-methyl-4-(2-thien-2-ylethoxy)phenoxy]acetate

intermediate 69

ethyl[2-methyl-4-(2-thien-2-ylethoxy)phenoxy]acetate

bromine

→

title compound

ethyl{4-[2-(5-bromothien-2-yl)ethoxy]-2-methylphenoxy}acetate

Растворители

acetic acid

Условия реакции

Обработка

1. 1
   Экстракцияthe resulting suspension extracted with diethyl ether
2. 2
   ДругоеThe organic layer was separated
3. 3
   Сушкаdried over sodium sulfate
4. 4
   Концентрированиеconcentrated

Методика

A solution of ethyl[2-methyl-4-(2-thien-2-ylethoxy)phenoxy]acetate (intermediate 69, 0.306 g) in acetic acid (5 ml) was treated with bromine (0.180 g) at ambient temperature and the mixture stirred for 15 minutes. The mixture was poured into water and the resulting suspension extracted with diethyl ether. The organic layer was separated, dried over sodium sulfate and concentrated to give the title compound as a colourless oil.

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