Реакция #974084

Уравнение реакции

tert-butyl 7-(morpholin-4-yl)-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate

hydrogen chloride-ethyl acetate

→

desired product

Выход 81.2%

7-(morpholin-4-yl)-2,3,4,5-tetrahydro-1,4-benzoxazepine dihydrochloride

Выход 81.2%

Растворители

ethyl acetate

Условия реакции

Обработка

1. 1
   Другоеthe solvent was evaporated under reduced pressure
2. 2
   ДругоеThe residue was recrystallized from a mixed solvent of methanol and ether

Методика

A mixture of tert-butyl 7-(morpholin-4-yl)-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate (180 mg, 0.538 mmol), ethyl acetate (1 ml) and 4N hydrogen chloride-ethyl acetate solution (4 ml) was stirred for 1 hr at room temperature, and the solvent was evaporated under reduced pressure. The residue was recrystallized from a mixed solvent of methanol and ether to give the desired product (134 mg, 81.2%) as a solid.

Источник