Реакция #973

Уравнение реакции

N-(5-fluoro-2-nitrophenyl)-S-methyl-L-cysteine

N-(5-Fluoro-2-nitrophenyl)-S-methyl-L-cysteine

sodium methoxide

→

N-(5-Methoxy-2-nitrophenyl)-S-methyl-L-cysteine

Растворители

methanol

Условия реакции

Обработка

1. 1
   Температураwhile cooling by means of an ice bath
2. 2
   ТемператураThe mixture is then heated
3. 3
   Температураto reflux for 2 hours
4. 4
   workup.STIRRINGwhile stirring

Методика

27 g of N-(5-fluoro-2-nitrophenyl)-S-methyl-L-cysteine (0.1 mol) from Example 1 are dissolved in 150 ml of absolute methanol in a four-necked flask, and 14.4 g of 95% sodium methoxide (0.25 mmol) are added in portions, within the space of 20 minutes and under argon, to this solution while stirring well and while cooling by means of an ice bath. The mixture is then heated to reflux for 2 hours while stirring. TLC monitoring then indicates that the reaction is complete.

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