Реакция #969877

Уравнение реакции

6-aminoquinoline

1-hydroxibenzotriazol

Z-Val-Pro-OH

N,N′-diisopropylcarbodiimide

→

Z-Val-Pro 6-aminoquinoline

Растворители

dichloromethane

Условия реакции

Обработка

1. 1
   Другоеwas continued until the complete disappearance of the starting material (overnight)
2. 2
   ДругоеThen, the solvent was evaporated
3. 3
   workup.DISSOLUTIONthe residue was dissolved in ethyl acetate
4. 4
   Промывкаwashed with citric acid (10%), NaHCO3 (10%) and brine
5. 5
   СушкаThe organic layer was dried (Na2SO4)
6. 6
   Другоеevaporated
7. 7
   Другоеleaving a residue that
8. 8
   Другоеwas purified by CCTLC on the chromatotron with hexane/ethyl acetate (1:4)
9. 9
   Другоеto yield H (20
10. 10
    Другоеyield

Методика

A solution of Z-Val-Pro-OH (217.4 mg, 0.62 mmol) in dichloromethane (1.5 mL), was successively treated at room temperature. with 1-hydroxibenzotriazol (84.3 mg, 0.62 mmol), N,N′-diisopropylcarbodiimide (97.2 μL, 0.62 mmol) and 6-aminoquinoline (75 mg, 0.52 mmol). The stirring was continued until the complete disappearance of the starting material (overnight). Then, the solvent was evaporated, the residue was dissolved in ethyl acetate and washed with citric acid (10%), NaHCO3 (10%) and brine. The organic layer was dried (Na2SO4) and evaporated leaving a residue that was purified by CCTLC on the chromatotron with hexane/ethyl acetate (1:4) to yield H (20 yield

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