Реакция #966785

Уравнение реакции

(R)-1-Boc-2-methylpiperazine

sodium triacetoxyborohydride

acetone

acetic acid

→

(S)-1-Boc-2-methyl-4-isopropylpiperazine

Растворители

DMF

water

Условия реакции

Обработка

1. 1
   Экстракцияextracted three times with diethyl ether
2. 2
   СушкаThe combined organics were dried over sodium sulfate
3. 3
   Фильтрацияfiltered
4. 4
   Концентрированиеconcentrated
5. 5
   Другоеused without further purification

Методика

To (R)-1-Boc-2-methylpiperazine (200.0 mg, 0.999 mmol) and sodium triacetoxyborohydride (444.5 mg, 2.097 mmol) in DMF (5 mL) was added acetone (116 mg, 0.147 mL, 1.997 mmol) and acetic acid (90.0 mg, 86 μL, 1.498 mmol). The reaction mixture was heated at 60° C. for 1 h. The reaction mixture was diluted with water and extracted three times with diethyl ether. The combined organics were dried over sodium sulfate, filtered, concentrated, and used without further purification. LCMS-ESI+: calc'd for C13H27N2O2 (M+H+): 243.2; Found: 243.2 (M+H+).

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