Реакция #9637

Уравнение реакции

bromobenzene

AlCl3

HCl

3-oxabicyclo[3.1.0]hexane-2,4-dione

→

cis-2-(4-bromobenzoyl)cyclopropanecarboxylic acid

Выход 74.6%

Растворители

DCM

Условия реакции

Обработка

1. 1
   workup.ADDITIONwas added
2. 2
   workup.STIRRINGThe solution was stirred for few minutes
3. 3
   Другоеthe layers were separated
4. 4
   ЭкстракцияThe aqueous layer was extracted with DCM
5. 5
   Промывкаthe combined organic phases were washed with water, brine
6. 6
   Сушкаdried over Na2SO4
7. 7
   Концентрированиеconcentrated

Методика

To a cold (0° C.) stirred solution of bromobenzene (9.09 g, 57.89 mmol) and AlCl3 (18.36 g, 137.84 mmol) in dry DCM (150 mL) was added 3-oxabicyclo[3.1.0]hexane-2,4-dione (5.40 g, 48.24 mmol). The reaction mixture was stirred at rt for 3 days. The dark-red solution was then poured into ice-cold water (120 mL), and conc. HCl (10 mL) was added. The solution was stirred for few minutes, and the layers were separated. The aqueous layer was extracted with DCM and the combined organic phases were washed with water, brine, dried over Na2SO4 and concentrated to give cis-2-(4-bromobenzoyl)cyclopropanecarboxylic acid (9.69 g, 65%). LC-MS ret. time 2.50; m/z 270 (MH+); 1H NMR (400 MHz, CD2Cl2) δ 1.54 (m, 1H), 1.85 (m, 1H), 2.37 (m, 1H), 2.88 (m, 1H), 7.65 (m, 2H), 7.90 (m, 2H).

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