Реакция #962

Уравнение реакции

(3RS)-1-benzyl-3-chloromethyl pyrrolidine

sodium cyanide

Water

→

product

Выход 92.0%

(3RS)-1-benzyl-3-cyanomethyl pyrrolidine

Выход 92.0%

Растворители

dimethyl sulfoxide

Условия реакции

Обработка

1. 1
   Экстракцияthe mixture was extracted three times with ethyl acetate
2. 2
   ПромывкаThe combined organic layer was washed with brine
3. 3
   Сушкаdried (Na2SO4)
4. 4
   Фильтрацияfiltered
5. 5
   Другоеevaporated

Методика

16.8 g (0.08 mole) (3RS)-1-benzyl-3-chloromethyl pyrrolidine and 5.88 g (0.12 mole) of sodium cyanide was dissolved in 250 ml dimethyl sulfoxide. The mixture was stirred at 60° C. for two days and at room temperature for one week. Water was added and the mixture was extracted three times with ethyl acetate. The combined organic layer was washed with brine, dried (Na2SO4), filtered and evaporated to yield 14.7 g (92%) of the product.

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