Реакция #955955

Уравнение реакции

acetic anhydride

butyl pyruvate

acetic anhydride

→

butyl α-acetoxyacrylate

Выход 67.1%

Растворители

acetic acid

Условия реакции

Обработка

1. 1
   workup.ADDITIONwas added
2. 2
   Другоеto obtain a second reaction solution
3. 3
   Другоеwas removed from the second reaction solution
4. 4
   workup.DISTILLATIONThereafter, the residue was purified by reduced pressure distillation (2 mmHg, 56 to 63° C.)

Методика

Next, in a mixture of the obtained butyl pyruvate (235 g, 1.6 mol) and acetic anhydride (333 g, 3.3 mol), p-toluenesulfonic acid monohydrate (5 g) was added. Then, the mixture was stirred under a nitrogen gas stream at 120° C. for 25 hours to obtain a second reaction solution. Next, acetic acid generated by a reaction with excess acetic anhydride under reduced pressure (5 mmHg) was removed from the second reaction solution. Thereafter, the residue was purified by reduced pressure distillation (2 mmHg, 56 to 63° C.) to obtain butyl α-acetoxyacrylate (200 g, yield 67%).

Источник