Реакция #955953

Уравнение реакции

acetic anhydride

ethyl pyruvate

acetic anhydride

→

ethyl α-acetoxyacrylate

Выход 58.5%

Растворители

acetic acid

Условия реакции

Обработка

1. 1
   workup.ADDITIONwas added
2. 2
   Другоеto obtain a reaction solution
3. 3
   Другоеwas removed from the reaction solution
4. 4
   workup.DISTILLATIONThereafter, the residue was purified by reduced pressure distillation (35 to 40 mmHg, 90 to 103° C.)

Методика

First, to a mixture of ethyl pyruvate (315 g, 2.7 mol) and acetic anhydride (554 g, 5.4 mol), p-toluenesulfonic acid monohydrate (8 g) was added. Then, the mixture was stirred under a nitrogen gas stream at 120° C. for 24 hours to obtain a reaction solution. Next, acetic acid generated by a reaction with excess acetic anhydride under reduced pressure (40 to 50 mmHg) was removed from the reaction solution. Thereafter, the residue was purified by reduced pressure distillation (35 to 40 mmHg, 90 to 103° C.) to obtain ethyl α-acetoxyacrylate (250 g, yield 58%).

Источник