Реакция #955938

Уравнение реакции

4-chloro-2-methoxybenzoic acid

MeOH

→

methyl 4-chloro-2-methoxybenzoate

Выход 96.0%

Растворители

H2SO4

Условия реакции

Обработка

1. 1
   Температураwas refluxed overnight
2. 2
   ДругоеMeOH was evaporated
3. 3
   Экстракцияthe residue was extracted to EtOAc
4. 4
   Промывкаsuccessively washed with water and brine
5. 5
   Сушкаdried over MgSO4
6. 6
   Фильтрацияfiltered
7. 7
   Другоеevaporated

Методика

A suspension of 4-chloro-2-methoxybenzoic acid (5 g, 27 mmol) in MeOH (18 mL) and conc. H2SO4 (1.5 mL) was refluxed overnight. MeOH was evaporated and the residue was extracted to EtOAc and successively washed with water and brine, dried over MgSO4, filtered and evaporated to give methyl 4-chloro-2-methoxybenzoate as a white solid (5.17 g, 96%).

Источник