Реакция #9548

Уравнение реакции

(7-bromo-3-nitroquinolin-4-yl)-(2-methylpropyl)amine

→

7-bromo-N4-(2-methylpropyl)quinoline-3,4-diamine

Растворители

acetonitrile

isopropanol

acetonitrile

isopropanol

Условия реакции

Обработка

1. 1
   Другоеthe vessel was purged with nitrogen
2. 2
   Другоеfor two hours
3. 3
   ФильтрацияThe reaction mixture was filtered through a layer of CELITE
4. 4
   Фильтрацияfilter aid
5. 5
   Промывкаthe filter cake was washed with acetonitrile
6. 6
   КонцентрированиеThe filtrate was concentrated under reduced pressure

Методика

A solution of (7-bromo-3-nitroquinolin-4-yl)-(2-methylpropyl)amine (30.9 g, 105 mmol) in acetonitrile (1.8 L) and isopropanol (200 mL) was added to a Parr vessel. A mixture of 5% platinum on carbon (3.0 g) and acetonitrile:isopropanol (20 mL) was added, and the vessel was purged with nitrogen. The vessel was placed under hydrogen pressure (40 psi, 2.8×105 Pa) for two hours. After one hour, the pressure had decreased to 20 psi (1.4×105 Pa) and was readjusted to 40 psi (2.8×105 Pa). The reaction mixture was filtered through a layer of CELITE filter aid, and the filter cake was washed with acetonitrile. The filtrate was concentrated under reduced pressure to provide 7-bromo-N4-(2-methylpropyl)quinoline-3,4-diamine as an oil.

Источник