Реакция #953485

Уравнение реакции

oxetane

N,N,N-trimethyl-[3-(methylamino)]-1-propanaminium bromide

→

3-[N'-(3-Hydroxypropyl)-N'-methylamino]-N,N,N-trimethyl-1-propanaminium Bromide

Растворители

water

Условия реакции

Обработка

1. 1
   workup.ADDITIONA mixture of 20 g
2. 2
   ДругоеThe solution is evaporated in vacuo
3. 3
   workup.DISSOLUTIONthe residue is dissolved in 50 ml
4. 4
   Фильтрацияof acetonitrile and filtered
5. 5
   ДругоеUpon evaporation the desired product
6. 6
   Другоеcrystallizes
7. 7
   ДругоеThe product may be recrystallized from acetonitrile

Методика

A mixture of 20 g. of oxetane (0.34 mole), 32.8 g. of N,N,N-trimethyl-[3-(methylamino)]-1-propanaminium bromide (0.156 mole) and 22 ml. water is heated in a sealed tube at 100° for 15 hours. The solution is evaporated in vacuo and the residue is dissolved in 50 ml. of acetonitrile and filtered. Upon evaporation the desired product crystallizes. The product may be recrystallized from acetonitrile.

Источник