Реакция #95223

Уравнение реакции

5-amino-3-trichloromethyl-1,2,4-thiadiazole

2,4-dichlorobenzoyl chloride

→

pure product

Выход 69.5%

5-(2,4-Dichlorobenzamido)-3-Trichloromethyl-1,2,4-Thiadiazole

Выход 69.5%

Растворители

xylene

Условия реакции

Обработка

1. 1
   КонцентрированиеThe reaction mixture was concentrated in vacuo
2. 2
   Экстракцияthe resulting residue extracted with benzene
3. 3
   workup.ADDITIONAddition of hexane

Методика

A solution of 10.9 g (0.05 mole) 5-amino-3-trichloromethyl-1,2,4-thiadiazole and 20.9 g (0.10 mole) 2,4-dichlorobenzoyl chloride was refluxed in 200 ml xylene for 20 hours. The reaction mixture was concentrated in vacuo and the resulting residue extracted with benzene. Addition of hexane resulted in precipitation of 13.6 g (69% yield) pure product; m.p. 136° C.

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