Реакция #95218

Уравнение реакции

5-amino-3-trichloromethyl-1,2,4-thiadiazole

4-nitrobenzoyl chloride

→

pure product

Выход 73.5%

5-(4-Nitrobenzamido)-3-Trichloromethyl-1,2,4-Thiadiazole

Выход 73.5%

Растворители

toluene

Условия реакции

Обработка

1. 1
   Температураat reflux for 20 hours
2. 2
   Другоеthe crude product precipitated from the reaction mixture
3. 3
   Другоеwas isolated by filtration
4. 4
   ПромывкаAfter washing with hexane

Методика

A solution of 10.9 g (0.05 mole) 5-amino-3-trichloromethyl-1,2,4-thiadiazole and 10.2 g (0.055 mole) 4-nitrobenzoyl chloride in 200 ml toluene was heated at reflux for 20 hours. Upon cooling to room temperature, the crude product precipitated from the reaction mixture and was isolated by filtration. After washing with hexane, 13.5 g (73% yield) of pure product was obtained; m.p. 214° C.

Источник