Реакция #951199

Уравнение реакции

4-[3-(2-aminobenzoylamino)propylthio]pyridine

1,1'-carbonyldiimidazole

→

desired product

Выход 65.7%

3-[3-(4-pyridylthio)propyl]-quinazoline-2,4(1H,3H)-dione

Выход 65.7%

Растворители

tetrahydrofuran

Условия реакции

Обработка

1. 1
   workup.DISTILLATIONThe solvent was distilled off
2. 2
   workup.DISSOLUTIONthe residue was dissolved in chloroform
3. 3
   ПромывкаThe solution was washed with water
4. 4
   Другоеdried
5. 5
   workup.DISTILLATIONThe solvent was distilled off
6. 6
   Другоеthe residue was recrystallized from ethanol/chloroform/ether

Методика

Under nitrogen atmosphere, to a solution of 718 mg (2.5 mmol) of 4-[3-(2-aminobenzoylamino)propylthio]pyridine in 15 ml of tetrahydrofuran, 811 mg (5.0 mmol) of 1,1'-carbonyldiimidazole was added, and the mixture was stirred at room temperature for 16 hours. The solvent was distilled off and the residue was dissolved in chloroform. The solution was washed with water and dried. The solvent was distilled off and the residue was recrystallized from ethanol/chloroform/ether to give 514 mg of the desired product (65.7% yield, white crystals).

Источник