Реакция #95016

Уравнение реакции

2-amino-5-methylpyrazine

bromine

sodium hydroxide

sodium acetate trihydrate

→

2-Amino-3-bromo-5-methylpyrazine

Растворители

acetic acid

acetic acid

acetic acid

Условия реакции

Обработка

1. 1
   Другоеat 2° C.
2. 2
   workup.ADDITIONpoured into ice
3. 3
   Фильтрацияfiltered
4. 4
   Экстракцияresidue extracted with ether
5. 5
   Другоеthe 2-amino-3-bromo-5-methylpyrazine crystallized from a suitable solvent

Методика

To acetic acid (1500 ml.), 2-amino-5-methylpyrazine (1 mole) and 326.5 g. sodium acetate trihydrate are slowly added 1.1 mole bromine in 180 ml. acetic acid at 2° C. in the absence of light. The mixture is stirred about 15 hours at 20° C., stripped of acetic acid in vacuo, poured into ice, made alkaline with sodium hydroxide, filtered, and residue extracted with ether, the extract stripped and the 2-amino-3-bromo-5-methylpyrazine crystallized from a suitable solvent.

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