Реакция #949656

Уравнение реакции

2-Hydroxyacetophenon

compound 1

2-Hydroxyacetophenon

pyrrolidine

piperidine

morpholine

→

compound 3

4-chromanon

Растворители

xylene

toluene

chlorobenzene

benzene

Условия реакции

Обработка

1. 1
   Температураabove are refluxed
2. 2
   Другоеwhile removing liberated water

Методика

2-Hydroxyacetophenon (compound 1, R1 is as defined above) and compound 2 wherein R2 and R3 are as defined above are refluxed under heating in a solvent such as benzene, chlorobenzene, toluene and xylene, in the presence of a secondary amine such as pyrrolidine, piperidine and morpholine, using a Dean-Stark apparatus, while removing liberated water to give 4-chromanon (compound 3 wherein R1, R2 and R3 are as defined above).

Источник