Реакция #94744

Уравнение реакции

1-(3',4'-dimethoxyphenyl)-7-phenyl-2-nitro-5-heptanone

p-toluenesulfonic acid

ethylene glycol

→

oil

1-(3',4'-dimethoxyphenyl)-7-phenyl-2-nitro-5-heptanone ethylene ketal

Растворители

cyclohexane

Условия реакции

Обработка

1. 1
   Другоеflask equipped with a Dean Stark trap
2. 2
   Температураto reflux overnight
3. 3
   Концентрированиеconcentrated in vacuo
4. 4
   workup.ADDITIONDil NaHCO3 solution was added to the residue
5. 5
   Экстракцияextracted with ethyl acetate
6. 6
   Сушкаdried over anh. MgSO4
7. 7
   Фильтрацияfiltered
8. 8
   Концентрированиеconcentrated under reduced pressure

Методика

Into a 1 l r.b. flask equipped with a Dean Stark trap was placed 46.4 g (0.12 m) of 1-(3',4'-dimethoxyphenyl)-7-phenyl-2-nitro-5-heptanone, 1.5 g p-toluenesulfonic acid, 50 mL of ethylene glycol and 300 mL of cyclohexane. The mixture was allowed to reflux overnight, then concentrated in vacuo. Dil NaHCO3 solution was added to the residue and extracted with ethyl acetate. The organic layer was backwashed with water, dried over anh. MgSO4, filtered and concentrated under reduced pressure to give 45.3 g of an oil which solidified on drying at room temperature under vacuum.

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