Реакция #9474

Уравнение реакции

Triethylamine

7-bromo-4-chloro-3-nitroquinoline

1-Amino-2-methylpropan-2-ol

→

1-(7-bromo-3-nitroquinolin-4-ylamino)-2-methylpropan-2-ol

Выход 78.5%

Растворители

dichloromethane

Условия реакции

Обработка

1. 1
   Температураto warm to ambient temperature
2. 2
   ДругоеA precipitate formed
3. 3
   Другоеwas isolated by filtration
4. 4
   Промывкаwashed with water
5. 5
   ДругоеThe crude solid was recrystallized from a mixture of isopropanol and acetonitrile

Методика

Triethylamine (17.35 mL, 124 mmol) was added to a solution of 7-bromo-4-chloro-3-nitroquinoline (29.84 g, 104 mmol) in dichloromethane (253 mL), and the reaction was cooled to 0° C. 1-Amino-2-methylpropan-2-ol (10.17 g, 114 mmol) was added dropwise, and then the reaction was allowed to warm to ambient temperature and stirred overnight. A precipitate formed and was isolated by filtration and washed with water. The crude solid was recrystallized from a mixture of isopropanol and acetonitrile to provide 27.78 g of 1-(7-bromo-3-nitroquinolin-4-ylamino)-2-methylpropan-2-ol as a solid.

Источник