Реакция #947

Уравнение реакции

Chlorosulphonic acid

product

(+-)-2-Amino-2-ethylhex-4-en-1-ol

→

desired product

Выход 57.0%

(+-)-2-But-2-enyl-2-ethylaziridine

Выход 57.0%

Растворители

acetonitrile

Условия реакции

Обработка

1. 1
   workup.ADDITIONWhen addition
2. 2
   ФильтрацияThe resulting crystals were filtered off
3. 3
   Промывкаwashed with acetonitrile/pet. ether
4. 4
   Другоеdried
5. 5
   workup.ADDITIONtaken up in a mixture of 50%
6. 6
   workup.DISTILLATIONKOH (100 mL) and water (55 mL) and distilled over KOH

Методика

Chlorosulphonic acid (18 mL) was added to a solution of the product from step (e) (32.3 g) in acetonitrile (100 ml) at least 9° C. When addition was complete, the mixture was warmed to room temperature. The resulting crystals were filtered off, washed with acetonitrile/pet. ether, dried, taken up in a mixture of 50% w/v aqu. KOH (100 mL) and water (55 mL) and distilled over KOH to give the desired product as a colourless oil (16.1 g). 1H NMR consistent with the proposed structure.

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