Реакция #945

Уравнение реакции

benzaldehyde

product

Ethyl 2-aminobutyrate hydrochloride

magnesium sulphate

triethylamine

→

desired product

Выход 88.9%

Ethyl 2-benzylideneaminobutyrate

Выход 88.9%

Растворители

dichloromethane

Условия реакции

Обработка

1. 1
   Фильтрацияthen filtered
2. 2
   КонцентрированиеThe filtrate was concentrated
3. 3
   Другоеtriturated in diethyl ether
4. 4
   Фильтрацияfiltered
5. 5
   Концентрированиеconcentrated

Методика

A solution of the product from step (a) (149.6 g), magnesium sulphate (74.3 g), and triethylamine (246 ml) in dichloromethane (1500 ml) was stirred at room temperature under nitrogen and benzaldehyde (94.9 g, Aldrich) was added dropwise. The mixture was stirred at room temperature for 3 hours then filtered. The filtrate was concentrated, triturated in diethyl ether, filtered and concentrated to yield the desired product as a yellow oil (174 g). 1H NMR consistent with the proposed structure.

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