Реакция #943989

Уравнение реакции

water

7-hydroxy-6-methoxy-1-tetralone

benzyl bromide

K2CO3

→

product

Выход 62.8%

7-Benzyloxy-6-methoxy-3,4-dihydro-2H-naphthalen-1-one

Выход 62.8%

Растворители

acetone

Условия реакции

Обработка

1. 1
   Температураwas heated
2. 2
   Температураto reflux overnight
3. 3
   ДругоеThe reaction
4. 4
   Температураas cooled
5. 5
   Экстракцияextracted with EtOAc
6. 6
   СушкаThe EtOAc was dried over Na2SO4
7. 7
   Другоеevaporated
8. 8
   Другоеto give 7 g of crude product
9. 9
   ДругоеCrystallization with Et2O

Методика

A mixture of 4.5 g (0.0233 mole) of 7-hydroxy-6-methoxy-1-tetralone, 5.4 g (0.032 mole) of benzyl bromide and 10 g (0.072 mole) of K2CO3 in 150 ml of acetone was heated to reflux overnight. The reaction as cooled, poured into water and extracted with EtOAc. The EtOAc was dried over Na2SO4 and evaporated to give 7 g of crude product. Crystallization with Et2O gave 4.13 g of product as a white solid, mp 110-111° C.

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