Реакция #94297

Уравнение реакции

Imidazo[1,5-a]pyridine

acetonitrile

α-bromotoluene

→

1-benzylimidazo[1,5-a]pyridinium bromide

Растворители

diethyl ether

Условия реакции

Обработка

1. 1
   Температураheated
2. 2
   Температураunder reflux for 3 hrs
3. 3
   ТемператураThe solution is cooled
4. 4
   workup.ADDITIONdiluted with 250 ml
5. 5
   ФильтрацияThe resulting precipitate is filtered
6. 6
   Другоеrecrystallized from isopropanol-diethyl ether, 7.92 g

Методика

Imidazo[1,5-a]pyridine (3.9 g.) in 100 ml. of dry acetonitrile is treated with 6.8 g. of α-bromotoluene, and the resulting reaction mixture heated under reflux for 3 hrs. The solution is cooled and diluted with 250 ml. of diethyl ether. The resulting precipitate is filtered and recrystallized from isopropanol-diethyl ether, 7.92 g., m.p. 172-176° C.

Источник