Реакция #94294

Уравнение реакции

2-(4-methoxyphenyl)imidazo[1,2-a]pyridine

methyl iodide

methyl iodide

→

1-methyl-2-(4-methoxyphenyl)imidazo[1,2-a]pyridinium iodide

Растворители

acetonitrile

Условия реакции

Обработка

1. 1
   Температураrefluxed for 3 hrs
2. 2
   Температураreflux
3. 3
   ДругоеThe solids which precipitate
4. 4
   Температураon cooling
5. 5
   Фильтрацияare filtered
6. 6
   workup.DISSOLUTIONpartially dissolved
7. 7
   Фильтрацияfiltered
8. 8
   ТемператураThe isopropanol filtrate is cooled
9. 9
   workup.ADDITIONtreated with diethyl ether
10. 10
    ФильтрацияThe crystallized product is filtered
11. 11
    Другоеdried
12. 12
    Другоеto give 1.03 g

Методика

To 2.23 g. of 2-(4-methoxyphenyl)imidazo[1,2-a]pyridine in 50 ml. of acetonitrile is added 2.84 g. of methyl iodide, and the resulting reaction mixture refluxed for 3 hrs. Additional methyl iodide (2 ml.) is added and reflux continued for one hour. The solids which precipitate on cooling are filtered and partially dissolved in boiling isopropanol and filtered. The isopropanol filtrate is cooled and treated with diethyl ether. The crystallized product is filtered and dried to give 1.03 g., m.p. 194-196° C.

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