Реакция #94084

Уравнение реакции

diethyl ketone

sodium methylate

3-ketobutan-1-ol

diethyl ketone

hydroquinone

→

2,3,6-trimethyl-2-cyclohexen-1-one

4-methyl-3-ethyl-2-cyclohexen-1-one

Растворители

methanol

Условия реакции

Обработка

1. 1
   Температураunder reflux
2. 2
   ТемператураThe reaction mixture is then heated
3. 3
   Температураunder reflux for another two hours
4. 4
   Другое37 g of water is removed from the reaction mixture by entrainment during the reaction

Методика

A mixture of 88 g of 3-ketobutan-1-ol, 150 g of diethyl ketone and 0.1 g of hydroquinone is dripped in the course of two hours into a mixture of 250 g of diethyl ketone and 10 g of a 30% by weight solution of sodium methylate in methanol which is boiling under reflux. The reaction mixture is then heated under reflux for another two hours. 37 g of water is removed from the reaction mixture by entrainment during the reaction. The whole is processed as described in Example 8. 73 g of 2,3,6-trimethyl-2-cyclohexen-1-one and 10 g of 4-methyl-3-ethyl-2-cyclohexen-1-one are obtained. The total yield of cyclohexenone is 60% with reference to 3-ketobutan-1-ol.

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