Реакция #939018

Уравнение реакции

sulfuric acid

butyl iodide

iodine

adipic acid monoethyl ester chloride

→

Ethyl 6-Oxodecanoate

Растворители

water

toluene

butyl acetate

Условия реакции

Обработка

1. 1
   Другоеto react
2. 2
   workup.ADDITIONwas added to the reaction solution
3. 3
   ЭкстракцияThe oily layer was extracted with ether
4. 4
   Промывкаwashed with aqueous sodium hydrogencarbonate
5. 5
   Промывкаwashed with water
6. 6
   Другоеdried
7. 7
   ДругоеThe residue was evaporated
8. 8
   Другоеto remove the solvent
9. 9
   workup.DISTILLATIONdistilled

Методика

A mixture of activated zinc-copper catalyst (11.5 g), butyl acetate (4 g), toluene (5 g), butyl iodide (15 g) and iodine (3 mg) was heated at 110-120° C. for 2 hours. The mixture was then added dropwise with adipic acid monoethyl ester chloride(15.7 g) at 0° C., and then was allowed to react. After the reaction was completed, ice-cooled water was added to the reaction solution, and then decomposed with dilute sulfuric acid. The oily layer was extracted with ether, washed with aqueous sodium hydrogencarbonate, washed with water, and then dried. The residue was evaporated to remove the solvent, and then distilled, thereby giving ethyl 6-oxodecanoate (8.1 g).

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