Реакция #937416

Уравнение реакции

1-(2-fluoro-4-dimethylbutylsilyloxyphenyl)-2-iodoethyne

copper cyanide

lithium bromide

hydrochloric acid

→

2-fluoro-4-hydroxyphenylpropiolonitrile

Растворители

tetrahydrofuran

Условия реакции

Обработка

1. 1
   Другоеthe solution was reacted
2. 2
   Температураunder reflux
3. 3
   Температураheating for 3 hours
4. 4
   ДругоеAfter completion of the reaction
5. 5
   Экстракцияextracted with toluene
6. 6
   СушкаThe organic layer was dried over anhydrous magnesium sulfate
7. 7
   Концентрированиеconcentrated under reduced pressure

Методика

To a solution of 25 mmol of 1-(2-fluoro-4-dimethylbutylsilyloxyphenyl)-2-iodoethyne in 50 ml of tetrahydrofuran were added copper cyanide and lithium bromide and the solution was reacted under reflux heating for 3 hours. After completion of the reaction, the solution was poured into a hydrochloric acid solution of ferric chloride and extracted with toluene. The organic layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to afford 20 mmol of 2-fluoro-4-hydroxyphenylpropiolonitrile as a colourless solid.

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