Реакция #93736

Уравнение реакции

tetrafluoroisophthalonitrile

sec-butanol

→

desired compound

Выход 89.0%

2,4,5-Trifluoro-6-sec-butoxyisophthalonitrile

Выход 89.0%

Растворители

acetonitrile

acetonitrile

Условия реакции

Обработка

1. 1
   ФильтрацияAfter the mixture was filtered
2. 2
   Концентрированиеthe filtrate was concentrated in vacuo
3. 3
   workup.ADDITIONthe concentrated liquid was poured into 50 ml of water
4. 4
   ЭкстракцияThe mixture was extracted with carbon tetrachloride
5. 5
   ПромывкаAfter washing with water
6. 6
   Сушкаthe resultant mixture was dried with anhydrous magnesium sulfate
7. 7
   workup.DISTILLATIONthe solvent was then distilled off

Методика

A 3.0 g amount of tetrafluoroisophthalonitrile and 1.26 g of 20 ml acetonitrile were dissolved in 20 ml of acetonitrile. A 1.66 g amount of sec-butanol was dropwise added to the mixture and the mixture was then stirred at room temperature for 24 hours. After the mixture was filtered, the filtrate was concentrated in vacuo and the concentrated liquid was poured into 50 ml of water. The mixture was extracted with carbon tetrachloride. After washing with water, the resultant mixture was dried with anhydrous magnesium sulfate and the solvent was then distilled off. Thus, 3.4 g (89% yield) of the desired compound No. 48 was obtained.

Источник