Реакция #93729

Уравнение реакции

sodium bicarbonate

tetrafluoroisophthalonitrile

triethylamine

aniline

→

desired compound

Выход 91.6%

4-Anilino-2,4,6-trifluoroisophthalonitrile

Выход 91.6%

Растворители

acetonitrile

acetonitrile

Условия реакции

Обработка

1. 1
   workup.ADDITIONAfter dropwise adding
2. 2
   ЭкстракцияThe mixture was extracted with chloroform
3. 3
   Экстракцияthe chloroform extract
4. 4
   Промывкаwas washed 5 times with an aqueous sodium chloride solution
5. 5
   СушкаAfter drying with magnesium sulfate
6. 6
   workup.DISTILLATIONthe chloroform was distilled off
7. 7
   ДругоеThe resultant crude crystal was purified by silica gel chromatography (solvent:hexane)

Методика

A solution of 0.85 g of aniline in 20 ml of acetonitrile was dropwise added, while stirring, to a solution of 2.0 g of tetrafluoroisophthalonitrile and 2.0 g of triethylamine in 30 ml of acetonitrile. After dropwise adding, the mixture was stirred at room temperature for 1 hour and an aqueous sodium bicarbonate solution was then added. The mixture was extracted with chloroform and the chloroform extract was washed 5 times with an aqueous sodium chloride solution. After drying with magnesium sulfate, the chloroform was distilled off. The resultant crude crystal was purified by silica gel chromatography (solvent:hexane). Thus, 2.3 g (87% yield) of the desired compound No. 6 was obtained.

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