Реакция #93542

Уравнение реакции

potassium hydroxide

α-methanesulfonyloxymethyl-β-(p-methoxyphenyl)-γ-butyrolactone

cyclohexylmercaptan

→

title compound

Выход 22.0%

α-cyclohexylthiomethyl-β-(p-methoxyphenyl)-γ-butyrolactone

Выход 22.0%

Растворители

ethanol

ethyl ether

Условия реакции

Обработка

1. 1
   ДругоеAfter completion of the reaction
2. 2
   Промывкаwashed with water and saturated saline
3. 3
   Сушкаdried over magnesium sulfate
4. 4
   workup.DISTILLATIONthe solvent was distilled off
5. 5
   ДругоеThe crude product thus obtained
6. 6
   Другоеwas purified by a silica gel column chromatography

Методика

To a solution of 480 mg of potassium hydroxide in 40 ml of ethanol were added 2.0 g of α-methanesulfonyloxymethyl-β-(p-methoxyphenyl)-γ-butyrolactone and 1.6 ml of cyclohexylmercaptan and the resulting mixture was kept at room temperature for 4 hours. After completion of the reaction, the reaction mixture was diluted with 200 ml of ethyl ether, washed with water and saturated saline, dried over magnesium sulfate and the solvent was distilled off. The crude product thus obtained was purified by a silica gel column chromatography to give 600 mg (yield 22%) of the title compound.

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