Реакция #93541

Уравнение реакции

sodium hydrosulfide

α-methanesulfonyloxymethyl-β-phenyl-γ-butyrolactone

β-(p-chlorophenyl)-α-methanesulfonyloxymethyl-γ-butyrolactone

acetic acid

→

title compound

Выход 52.0%

α-mercaptomethyl-β-phenyl-γ-butyrolactone

Выход 52.0%

Растворители

ethyl acetate

ethanol

Условия реакции

Обработка

1. 1
   ДругоеAfter completion of the reaction
2. 2
   Промывкаwashed with water in a conventional manner
3. 3
   Сушкаdried over magnesium sulfate
4. 4
   workup.DISTILLATIONthe solvent was distilled off
5. 5
   ДругоеThe crude product thus obtained
6. 6
   Другоеwas purified by a column chromatography

Методика

To a solution of 1.0 g of α-methanesulfonyloxymethyl-β-phenyl-γ-butyrolactone (III) in 20 ml of ethanol were added 1.5 ml of acetic acid and then 1.2 g of commercially available 70% sodium hydrosulfide and the mixture was stirred at room temperature for 18 hours. After completion of the reaction, the reaction mixture was diluted with 150 ml of ethyl acetate, washed with water in a conventional manner, dried over magnesium sulfate and the solvent was distilled off. The crude product thus obtained was purified by a column chromatography to give 400 mg (yield 52%) of the title compound.

Источник