Реакция #93539

Уравнение реакции

β-(p-chlorophenyl)-α-methylene-γ-butyrolactone

thiobenzoic acid

→

title compound

Выход 75.0%

α-benzoylthiomethyl-β-(p-chlorophenyl)-γ-butyrolactone

Выход 75.0%

Растворители

toluene

ethyl ether

Условия реакции

Обработка

1. 1
   Промывкаwashed with water and saturated saline
2. 2
   Сушкаdried over magnesium sulfate
3. 3
   workup.DISTILLATIONthe solvent was then distilled off
4. 4
   ДругоеThe crude product thus obtained
5. 5
   Другоеwas purified by a silica gel column chromatography

Методика

To a solution of 600 mg of β-(p-chlorophenyl)-α-methylene-γ-butyrolactone in 10 ml of toluene were added 0.44 ml of thiobenzoic acid and one drop of triethylamine and the reaction was effected at room temperature for 18 hours. The reaction mixture was diluted with 100 ml of ethyl ether, washed with water and saturated saline, dried over magnesium sulfate and the solvent was then distilled off. The crude product thus obtained was purified by a silica gel column chromatography to give 750 mg (yield 75%) of the title compound.

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