Реакция #935343

Уравнение реакции

2-hydroxyacetophenone

pyridine-4-carbaldehyde

hydrochloric acid

sodium hydroxide

→

1-(2-hydroxyphenyl) 3-(4-pyridyl) 3-hydroxy 1-propanone

Растворители

ethanol

Условия реакции

Обработка

1. 1
   workup.DISSOLUTIONAn abundant yellow precipitate forms at first which then gradually dissolves
2. 2
   ДругоеThe yellow precipitate obtained
3. 3
   Фильтрацияis filtered
4. 4
   Промывкаwashed with water
5. 5
   Другоеdried

Методика

According to the method of Corvaisier (Bull. Soc. Chim. Fr. 1962, 528) 15 ml of an 11 N aqueous sodium hydroxide solution are added to a solution of 24 g of 2-hydroxyacetophenone and 21 g of pyridine-4-carbaldehyde in 130 ml of absolute ethanol maintained an ambient temperature. An abundant yellow precipitate forms at first which then gradually dissolves. After two hours at ambient temperature the mixture is adjusted to pH 1 by means of hydrochloric acid. The yellow precipitate obtained is filtered, washed with water and dried. 27 g of 1-(2-hydroxyphenyl) 3-(4-pyridyl) 3-hydroxy 1-propanone melting at 150° C. are obtained.

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