Реакция #9351

Уравнение реакции

4-benzyloxyphenol

allylbromide

K2CO3

acetone

→

desired product

2,6-diallyl-4-benzyloxyphenol

Условия реакции

Обработка

1. 1
   ТемператураThe reaction mixture was refluxed overnight
2. 2
   Другоеthe insoluble materials were removed by filtration
3. 3
   КонцентрированиеThe filtrate was concentrated in vac
4. 4
   ДругоеThe residue was partitioned between ethyl ether (500 mL) and 2N aqueous NaOH (200 mL)
5. 5
   ПромывкаThe organic layer was washed with water and brine
6. 6
   Сушкаdried over anhydrous MgSO4
7. 7
   Фильтрацияfiltered
8. 8
   Концентрированиеconcentrated in vac

Методика

To a solution of starting 4-benzyloxyphenol (20 g) in acetone (800 mL) were added allylbromide (50 mL) and K2CO3 (60 g). The reaction mixture was refluxed overnight. After cooling to the room temperature, the insoluble materials were removed by filtration. The filtrate was concentrated in vac. The residue was partitioned between ethyl ether (500 mL) and 2N aqueous NaOH (200 mL). The organic layer was washed with water and brine, dried over anhydrous MgSO4, filtered, and concentrated in vac. to give the desired product.

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