Реакция #93370

Уравнение реакции

alpha-isopropyl-alpha-[2-[N-[3-(2-methoxyphenoxy)propyl]amino]ethyl]-3,4,5-trimethoxyphenylacetonitrile

formalin

formic acid

potassium carbonate

→

desired compound

Alpha-isopropyl-alpha-[2-[N-[3-(2-methoxyphenoxy)propyl]-N-methylamino]ethyl]-3,4,5-trimethoxyphenylacetonitrile

Растворители

water

Условия реакции

Обработка

1. 1
   Температураwas refluxed for 1 hour
2. 2
   ТемператураAfter cooling, to the mixture
3. 3
   ЭкстракцияThe solution was extracted with chloroform
4. 4
   ПромывкаThe extract was washed with water
5. 5
   Другоеdried
6. 6
   Другоеevaporated

Методика

A mixture of 0.39 g of alpha-isopropyl-alpha-[2-[N-[3-(2-methoxyphenoxy)propyl]amino]ethyl]-3,4,5-trimethoxyphenylacetonitrile, 1 ml of 37% formalin, and 1 ml of 90% formic acid was refluxed for 1 hour. After cooling, to the mixture were added water and potassium carbonate to make it alkaline. The solution was extracted with chloroform. The extract was washed with water, dried, and evaporated to give 0.23 g of desired compound as a yellow oil.

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