Реакция #93333

Уравнение реакции

methyl iodide

(1RS, 3SR)-trans-3-hydroxymethyl-1-methyl-1,2,3,4-tetrahydro-β-carboline

triethylamine

CS2

→

Methyl (1RS, 3SR)-trans-3-hydroxymethyl-1-methyl-1,2,3,4-tetrahydro-β-carboline-2-carbodithioate

Растворители

dimethylsulfoxide

Условия реакции

Обработка

1. 1
   Другоеis prepared
2. 2
   Другоеthe title compound (1.22 g, 79.7%) as colorless needles, m.p. 153°-156° C. (recrystallized from aqueous methanol)

Методика

In the same manner as described in Example 13 by using (1RS, 3SR)-trans-3-hydroxymethyl-1-methyl-1,2,3,4-tetrahydro-β-carboline (1.08 g), triethylamine (1.01 g), CS2 (760 mg), methyl iodide (1.42 g) and dimethylsulfoxide (10 ml), there is prepared the title compound (1.22 g, 79.7%) as colorless needles, m.p. 153°-156° C. (recrystallized from aqueous methanol). NMR (CDCl3, δ): 2.60 (d, J=7.0 Hz, 3H, C1 --CH3), 2.68 (s, 3H, CSSCH3), Mass m/e: 306 (M+), 258 (M+ --CH3SH).

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