Реакция #93286

Уравнение реакции

Methane sulfonyl chloride

product

4-Hydroxy-8-methoxy-2,3-dihydrobenzopyran

triethylamine

piperidine

→

desired product

8-Methoxy-4-piperidino-2,3-dihydrobenzopyran

Растворители

methylene chloride

Условия реакции

Обработка

1. 1
   workup.STIRRINGthe reaction mixture is stirred under nitrogen overnight
2. 2
   ПромывкаThe reaction mixture is washed with sat'd aq. sodium bicarbonate
3. 3
   Другоеdried
4. 4
   Фильтрацияfiltered
5. 5
   Другоеevaporated in vacuo

Методика

Methane sulfonyl chloride (14.9 ml) is added dropwise to a solution of the product obtained in Step 1. (31.6 g) and triethylamine (29.3 ml) in methylene chloride (750 ml) cooled to 0° C. under nitrogen. The reaction mixture is stirred for 11/2 hours; piperidine (175 ml) is added and the reaction mixture is stirred under nitrogen overnight. The reaction mixture is washed with sat'd aq. sodium bicarbonate, sat'd NaCl, dried, filtered and evaporated in vacuo yielding the desired product as its hydrochloride salt.

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