Реакция #93251

Уравнение реакции

12-acetyl-5,6-diacetoxy-12H-benzo[a]phenothiazine

sodium hydroxide

acetic acid

→

title compound

Выход 28.0%

12-Acetyl-5,6-dihydroxy-12H-benzo[a]phenothiazine

Выход 28.0%

Растворители

acetone

Условия реакции

Обработка

1. 1
   Фильтрацияthe insolubles filtered
2. 2
   Промывкаwashed with water

Методика

To a suspension of 12-acetyl-5,6-diacetoxy-12H-benzo[a]phenothiazine (450 mg) in acetone (10 ml) there was added 2N aqueous sodium hydroxide solution (10 ml) and the resulting mixture was stirred at room temperature for 45 minutes. It was then made slightly acidic by the addition of 10% aqueous acetic acid solution and the insolubles filtered and washed with water. The solid was swished in ethyl acetate to afford pure title compound (100 mg), m.p. 258°-260° C.

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