Реакция #931

Уравнение реакции

water

2,6-dinitrobenzonitrile

K2CO3

3,5-dimethylthiophenol

→

2-[(3,5-dimethylphenyl)thio]-6-nitrobenzonitrile

Растворители

DMF

DMF

Условия реакции

Обработка

1. 1
   workup.STIRRINGAfter stirring an additional 30 min
2. 2
   workup.STIRRINGstirred for 1 hr
3. 3
   ФильтрацияThe solid was collected by vacuum filtration

Методика

A mixture of 2,6-dinitrobenzonitrile (1.4 g 7.2 mmol) and K2CO3 (1.1 g, 7.9 mmol) in 10 ml of DMF was chilled to 0° C. A solution of 3,5-dimethylthiophenol (1.1 g 0.0079 mmol) in 10 ml of DMF, was added dropwise over 30 min with stirring under nitrogen. After stirring an additional 30 min, the reaction mixture was poured into 150 ml of water and stirred for 1 hr. The solid was collected by vacuum filtration. Chromatography on silica gel (flash; Hex/EtOAc 1:1) provided 1.64 g (80%) of 2-[(3,5-dimethylphenyl)thio]-6-nitrobenzonitrile: mp 155°-156° C.

Источник