Реакция #92923

Уравнение реакции

NaOH

2-(4-ethynylphenyl)-3-methyl-1-(1H-1,2,4-triazole-1-yl)butan-2-ol

CH3OH

iodine

→

title compound

2-(4-Iodoethynylphenyl)-3-methyl-1-(1H-1,2,4-triazole-1-yl)butan-2-ol

Растворители

H2O

Условия реакции

Обработка

1. 1
   workup.STIRRINGwith stirring
2. 2
   Экстракцияextracted with CH2Cl2
3. 3
   ПромывкаThe organic phase is washed
4. 4
   Другоеdried
5. 5
   Другоеevaporated
6. 6
   workup.STIRRINGThe residue is stirred in hexane fraction
7. 7
   Другоеdried

Методика

To a solution of 5.1 g 2-(4-ethynylphenyl)-3-methyl-1-(1H-1,2,4-triazole-1-yl)butan-2-ol in 100 ml abs. CH3OH are simultaneously added, with stirring at 20°-25°, 2.6 g iodine and 10 ml 30% NaOH solution. The reaction mixture is maintained at room temperature for 24 hours, with stirring, then poured into 500 ml H2O and extracted with CH2Cl2. The organic phase is washed, dried and evaporated. The residue is stirred in hexane fraction and kept over 16 hours at rest. The precipitate is sucked off and dried to give the title compound m.p. 122° as colourless crystals.

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