Реакция #92756

Уравнение реакции

Carbodiimide

8-(cyclohexylmethoxy)-2-methylimidazo[1,2-a]pyridine-3-carboxylic acid

cyclopropylamine

1-hydroxybenzotriazole

diisopropylethylamine

Isocyanate

triethylammonium

Carbonate

→

8-(cyclohexylmethoxy)-N-cyclopropyl-2-methylimidazo[1,2-a]pyridine-3-carboxamide

Выход 88.1%

Растворители

DMF

DMF

Условия реакции

Обработка

1. 1
   workup.STIRRINGby stirring at room temperature for 3 hours
2. 2
   ДругоеThe resin of the reaction mixture was removed by filtration
3. 3
   Концентрированиеthe filtrate was concentrated under reduced pressure
4. 4
   ДругоеThe obtained residue was purified by preparative HPLC (high performance liquid chromatography)

Методика

To a mixture of 8.7 mg of 8-(cyclohexylmethoxy)-2-methylimidazo[1,2-a]pyridine-3-carboxylic acid, 5.1 mg of cyclopropylamine, 4.1 mg of 1-hydroxybenzotriazole, 1 ml of DMF, and 28 μl of diisopropylethylamine was added 50 mg of polystyrene N-cyclohexylcarbodiimide-N′-propyloxymethyl (PS-Carbodiimide manufactured by Biotage), followed by stirring at room temperature for 16 hours. Subsequently, 1 ml of DMF, 50 mg of macroporious triethylammonium methylpolystyrene carbonate (MP-Carbonate manufactured by Biotage) and 50 mg of polystyrene methyl isocyanate (PS-Isocyanate manufactured by Biotage), followed by stirring at room temperature for 3 hours. The resin of the reaction mixture was removed by filtration and the filtrate was concentrated under reduced pressure. The obtained residue was purified by preparative HPLC (high performance liquid chromatography) to obtain 8.7 mg of 8-(cyclohexylmethoxy)-N-cyclopropyl-2-methylimidazo[1,2-a]pyridine-3-carboxamide.

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