Реакция #9264

Уравнение реакции

2-amino-1,3-benzothiazole-6-carbonitrile

ethylisocyanate

triethylamine

→

N-(6-Cyano-1,3-benzothiazol-2-yl)-N′-ethylurea

Растворители

dimethylformamide

Условия реакции

Обработка

1. 1
   Температураthen cooled to RT
2. 2
   ДругоеThe solvent is removed in vacuo
3. 3
   Промывкаthe solids are washed well with ether
4. 4
   ДругоеThe product is further purified by column chromatography
5. 5
   Другоеafter drying in vacuo
6. 6
   Другоеabout 0.14 grams is isolated

Методика

0.2 grams of 2-amino-1,3-benzothiazole-6-carbonitrile is dissolved in about 5 ml dimethylformamide. About 0.2 ml of ethylisocyanate is added followed by about 0.3 ml triethylamine and the solution is heated to about 80° C. under good agitation. The solution is allowed to stir for about 4 hours then cooled to RT. The solvent is removed in vacuo and the solids are washed well with ether. The product is further purified by column chromatography and after drying in vacuo, about 0.14 grams is isolated.

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