Реакция #924

Уравнение реакции

methyl chloroformate

N-(1,1-dimethylethyl)-1-methyl-1H-pyrrole-2-sulfonamide

n-butyllithium

→

title compound

Выход 14.3%

Methyl 2-[[(1,1-Dimethylethyl)amino]sulfonyl]-1-methyl-1H-pyrrole-3-carboxylate

Выход 14.3%

Растворители

THF

ethyl acetate

THF

Условия реакции

Обработка

1. 1
   Другоеthe temperature below -58° C
2. 2
   Другое1 h
3. 3
   Другоеat 0° C.
4. 4
   Другоеwas recooled to -70° C.
5. 5
   workup.STIRRINGThe reaction mixture was stirred overnight at ambient temperature
6. 6
   ПромывкаThis solution was washed successively with two 60 mL portions of 1N HCl, brine
7. 7
   Сушкаdried (Na2SO4)
8. 8
   Другоеevaporated to a dark oil
9. 9
   ДругоеThe crude product was purified by chromatography on silica gel (30% ethyl acetate/70% hexanes)
10. 10
    Другоеthen collected from hexanes

Методика

To a solution of 2.5 g (11.5 mmol) of N-(1,1-dimethylethyl)-1-methyl-1H-pyrrole-2-sulfonamide in 50 mL THF under nitrogen atmosphere cooled to below -70° C. was added dropwise 13 mL (32.5 mmol) of 2.5M n-butyllithium at such a rate as to keep the temperature below -58° C. After stirring at -20° C. to -10° C. for 30 min then 1 h at 0° C., the mixture was recooled to -70° C. and treated with a solution of 1.63 g (17.3 mmol) of methyl chloroformate in 6 mL THF causing an exotherm to -57° C. The reaction mixture was stirred overnight at ambient temperature then diluted with 200 mL of ethyl acetate. This solution was washed successively with two 60 mL portions of 1N HCl, brine, then dried (Na2SO4) and evaporated to a dark oil. The crude product was purified by chromatography on silica gel (30% ethyl acetate/70% hexanes) then collected from hexanes to afford 0.45 g of the title compound, m.p. 105°-108° C.

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