Реакция #92324

Уравнение реакции

t-Butyl {[(1R,2R,5S)-5-(dimethylcarbamoyl)-2-hydroxycyclohexyl]sulfamoyl}carbamate

p-toluenesulfonyl chloride

N-methylimidazole

→

title compound

Выход 38.0%

(1R,2R,4S)-2-{[(t-Butoxycarbonyl) sulfamoyl]amino}-4-(dimethylcarbamoyl)cyclohexyl 4-methylbenzenesulfonate

Выход 38.0%

Растворители

dichloromethane

Условия реакции

Обработка

1. 1
   ДругоеThereafter, the reaction mixture was purified by silica gel column chromatography

Методика

t-Butyl {[(1R,2R,5S)-5-(dimethylcarbamoyl)-2-hydroxycyclohexyl]sulfamoyl}carbamate (200 mg) was dissolved in dichloromethane (2.0 mL), and p-toluenesulfonyl chloride (136 mg) and N-methylimidazole (87.0 mL) were then added to the obtained solution. The obtained mixture was stirred at room temperature for approximately 20 hours. Thereafter, the reaction mixture was purified by silica gel column chromatography to obtain the title compound (107 mg, yield: 38%) in the form of powder.

Источник