Реакция #92105

Уравнение реакции

isoquinolin-5-amine

DIEA

isocyanatocyclopentane

→

1-Cyclopentyl-3-(isoquinolin-5-yl)urea

Растворители

DCM

Условия реакции

Обработка

1. 1
   Другоеthe reaction was quenched with H2O (15 mL)
2. 2
   Экстракцияextracted with EtOAc (3×30 mL)
3. 3
   ПромывкаThe combined organic layers were washed with brine (10 mL)
4. 4
   Сушкаdried (MgSO4)
5. 5
   ДругоеThe impure yellow solid was collected

Методика

To isoquinolin-5-amine (0.23 g, 1.595 mmol) in DCM (5 mL) was added DIEA (0.557 mL, 3.19 mmol) and isocyanatocyclopentane (0.180 mL, 1.595 mmol). After 24 h, the reaction was quenched with H2O (15 mL) and extracted with EtOAc (3×30 mL). The combined organic layers were washed with brine (10 mL) and dried (MgSO4). The impure yellow solid was collected and was carried onto the next step. MS (ESI) m/z: 256 (M+H)+.

Источник