Реакция #91879

Уравнение реакции

6-chloro-2-(methylsulfinyl)pyrimidine-4-amine

N-bromosuccinimide

→

5-bromo-6-chloro-2-(methylthio)pyrimidine-4-amine

Растворители

DCM

Условия реакции

Методика

To a cold stirring solution of 10 g (52.2 mmol) 6-chloro-2-(methylsulfinyl)pyrimidine-4-amine in 450 ml of DCM, 10 g (56.2 mmol) of N-bromosuccinimide were added, and stirring was continued for 1 hour at room temperature to provide 5-bromo-6-chloro-2-(methylthio)pyrimidine-4-amine, which was used without further purification in the next step (see intermediate 3). The end of the reaction is followed by thin layer chromatography.

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