Реакция #9064

Уравнение реакции

4-(Benzimidazol-2-yl)-benzyl alcohol

→

4-(benzimidazol-2-yl)-benzaldehyde

Выход 42.0%

Растворители

CH2Cl2

THF

Условия реакции

Обработка

1. 1
   ФильтрацияThe mixture was filtered through celite
2. 2
   Промывкаthe cake washed with CH2Cl2
3. 3
   Другоеthe solvent from the eluent removed under reduced pressure

Методика

4-(Benzimidazol-2-yl)-benzyl alcohol from above (0.175 g, 0.78 mmol) was dissolved in CH2Cl2 (5 mL) and THF (8 mL), treated with activated MnO2 (0.68 g, 7.8 mmol) and stirred at room temperature for 1.5 h. The mixture was filtered through celite, the cake washed with CH2Cl2 and the solvent from the eluent removed under reduced pressure to afford 4-(benzimidazol-2-yl)-benzaldehyde (92 mg, 42%). 1H NMR (CD4OD) δ 7.28 (m, 2H), 7.60 (br, 1H (NH)), 7.65 (d, 2H, J=7.8 Hz), 8.09 (d, 2H, J=7.8 Hz), 8.30 (d, 2H, J=9.0 Hz), 10.08 (s, 1H (CHO)).

Источник